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Chunk #3 — Introduction

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Alcohol Dependence Genetics: Lessons Learned From Genome-Wide Association Studies (GWAS) and Post-GWAS Analyses.
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Here we summarize findings from all identified published classical GWAS of AD, discuss the knowledge that has been gained and the lessons learned from these studies, and provide an overview of the emerging post-GWAS approaches being used to study the genetics of AD. To identify studies, we used the PubMed and Google Scholar databases and searched for all English-language articles using combinations of the following search terms: genome-wide association study (GWAS), alcohol, alcohol dependence (AD), GCTA, profile score, gene set, and pathway analysis.