compute a score Si as the running average of values from the first position to position i. We then define the enrichment score E as the maximum of the absolute value of Si for all values of i>10. We require i>10 to avoid small fluctuations in the beginning of the ranked list causing fluctuations in the enrichment score. This score is computed for each lincRNA knockdown by functional set. Since we have many lincRNA knockdowns and functional sets, in reality we have a matrix of scores and we will refer to the enrichment score of the ith knockdown and jth functional set as Eij.