has evidence of DNA looping interactions with NEGR1. The association in SOX5 (rs4074723) and the two statistically independent associations in RBFOX1 (rs8063603 and rs7198928, P=6.9×10−9 and 1.0×10−8) had only intragenic associations, suggesting that the genetic variation in the regions of the major depression associations act locally and can be assigned to these genes. In contrast, the association in RERE (rs159963 P=3.2×10−8) could not be assigned to RERE as it may contain super-enhancer elements given its many DNA-DNA interactions with many nearby genes (Supplementary Fig. 3b).
