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Chunk #0 — Introduction

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Analysis of induced pluripotent stem cells carrying 22q11.2 deletion.
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Schizophrenia is a debilitating mental illness, with a prevalence of approximately 1% worldwide, making it a relatively common disease. Although a complete understanding of the pathological architecture is still elusive, the genetic components are thought to consist of numerous weak, risk-conferring genomic variations and/or rare and large effect-size variations. Rare structural variations (copy number variants) contribute to genetic risk for neurodevelopmental disorders such as schizophrenia.1, 2