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Chunk #19 — RESULTS — Dendritic Complexity

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Postnatal binge-like alcohol exposure decreases dendritic complexity while increasing the density of mature spines in mPFC Layer II/III pyramidal neurons.
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Repeated measures ANOVA was used to compare Sholl analyses between groups, in particular looking at ring (distance from soma) × treatment interaction. Results demonstrate a significant interaction between ring intersection and postnatal treatment (F(5.512, 30)=2.658, p=.036) Furthermore, T-tests for individual intersections found AE animals to have significantly less intersections than SC animals at 60μm (p <.05), at 80μm (p<.01) and at 100μm (p<.01). SI animals also have significantly less intersections than SC animals at 60μm (p<.05) (Figure 3).