phenotypic variance in SRE scores; examples may include diet, pubertal status, or psychological stressors with physiological consequences. While we understand a great deal about alcohol metabolism via alcohol dehydrogenases and other pathways (Lieber, 2005; Marshall and Chambers, 2005), the subjective experience of drinkers is likely influenced by a wider range of genetic factors, the identification of which is critical to developing a comprehensive model of risk.
