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Chunk #9 — Studying Fine-scale Recombination with Increased Sample Size

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Detection of sharing by descent, long-range phasing and haplotype imputation.
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There is much interest in recombination hotspots and their evolution8-10. Apart from methods that estimate historic recombination rates based on linkage disequilibrium (LD) patterns, a recent study investigated recombination events directly utilising high-density SNP data from 725 related individuals falling into 82 nuclear families11. A number of interesting observations were made even though there was only information on 728 meioses.