The disinhibition scale score was significantly associated with both trajectory membership and all peer cannabis use comparisons, while thrill-seeking was only significantly associated with belonging to the high trajectory class vs.no-low class and with the peer cannabis use comparison between none vs. a few (details in Table S6). Cannabis use PRS did not significantly predict either scale, but was significantly associated with conduct disorder diagnosis, as were peer use and all three of the trajectory class comparisons (Table S6). The association between peer use and trajectory membership (high vs. no-low class: p < 0.001; high vs. moderate: p = 0.037; moderate vs. no-low: p = < 0.001) was only somewhat attenuated when including conduct disorder as a covariate. Inclusion of conduct disorder also modestly attenuated the association between PRS and class membership (e.g., high vs. no-low class: ORconduct = 1.37, 95% CI = [1.11, 1.69], p = 0.003; vs ORno-conduct: 1.40, 95% CI = [1.13, 1.74], p = 0.002; high vs. moderate ORconduct = 1.45, 95% CI = [1.10, 1.90], p = 0.008 vs. ORno-conduct= 1.49, 95% CI = [1.12, 1.97], p = 0.006).
