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Chunk #0 — INTRODUCTION

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Acute alcohol response phenotype in heavy social drinkers is robust and reproducible.
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Replication is a fundamental component of the scientific method, and while it adds credence to the validity of original results, the majority of scientists devote most of their resources to producing new work rather than replicating their own or that of others (Collaboration, 2012; Nosek et al., 2012). Accordingly, there is a paucity of psychology studies that attempt to directly replicate previously published results using the same subject population and methodology as the original study (Ioannidis, 2005; Koole and Lakens, 2013; Makel et al., 2012; Roediger, 2012). Due to some recent large-scale failures to replicate in the medical field, with only 11% of high-impact findings in preclinical cancer research successfully replicated, there has been a renewed focus on the importance of reproducibility of novel and influential results in various fields of science (Begley and Ellis, 2012). The pharmaceutical industry also has shown difficulty in reproducing previous results, with one company replicating only 25 % of its previously published findings (Prinz et al., 2011). In light of such problems, researchers from the fields of psychology, oncology, and biomedicine have urged other