The overall AUD severity component seen in Fig. 2 is consistent with previously reported AUD factors (Rist, Glöckner-Rist, & Demmel, 2009; Shevlin & Smith, 2007), where two factors, one representing alcohol related problems and the second direct alcohol use, were sufficient to explain the variance in the AUDIT assessment. These previous reports do not include ADS and ICS assessments, however our results suggest a single combined problem and use factor is sufficient to explain the majority of the variance contained in the combined assessments. This component is consistently produced over varying component numbers. Subjects with large weights in these AUD assessments also show small overall gray matter, cerebellar and caudate volumes as well as large white matter and ventricle volumes with a correlation of 0.41, p < 0.05 corrected. This volumetric variation association with alcohol use disorder is in accord with previously reported results (Durazzo et al., 2011; Fein et al., 2002; Mattson et al., 1996; Sullivan et al., 2000). While overall gray and white matter volume variations can be considered a gross measure of structural differences we focus more
