versus high-alcohol–preferring rats. Likewise, Heath and colleagues (2011) examined a quantitative factor score created from items assessing quantity and frequency of consumption, frequency of intoxication, and maximum drinks in a single 24-hour period, all reported for the 12-month period when the participants indicated that they drank the heaviest. The results implicated variants in the TMEM108 gene, which encodes a transmembrane protein of unknown function (P = 1.2 × 10−7). These two initial studies of alcohol consumption implicate different genomic regions, and their findings have not converged. With larger sample sizes, it will become clearer whether these results represent true findings.
