The NIMH Autism Genetics Initiative maintains a collection of DNA from multiplex and simplex families with ASD. We genotyped individuals from 341 nuclear families, 258 of which were independent of the AGRE dataset, with at least one child meeting criteria for autism by the ADI-R, and a second child considered affected using the same criteria as described for the AGRE dataset above. Similar exclusion criteria were used, including known chromosomal abnormalities and excess non-Mendelian inheritance. The self-reported race/ethnicity of these samples is 83% white, 4% Hispanic, 2% unknown, 7% mixed, 3% Asian, and 1% African American.
