increased perceptions of “high” and “intoxicated” measured at the same BrAC and elapsed time on the ascending versus descending limb in moderate drinkers, and the reverse of that pattern in light drinkers. 27 Thus, the precise exposure control provided by IV alcohol administration techniques supports a relationship between positive and negative rates of change of BrAC and response to alcohol, drinking history, and other AUD risk factors. Taken together, the observations across the oral and IV alcohol challenge literature invited a study of how the steepness of self‐controlled positive rates of change in BrAC relate to the subjective response to alcohol, family history, recent drinking history and risk for AUD.
