GO pathway analysis revealed that DEGs between BPD and controls were enriched in protein transport as well as post-Golgi transport pathways. Interestingly, GeneGo analysis also identified clathrin-coated vesicle as well ER-to-Golgi processes. Chen et al [15] identified protein transport in their pathway analyses of DEGs in post-mortem BPD brains. This suggests that disruption of vesicular trafficking and protein transport may play a role in BPD and is supported by other recent genomic and proteomic findings implicating the clathrin interactome in psychiatric disorders including BPD [54].
