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Chunk #20 — Results — Individual-level analysis

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A total-population multigenerational family clustering study of autoimmune diseases in obsessive-compulsive disorder and Tourette's/chronic tic disorders.
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Individuals with OCD had a 43% increased risk of any AD, compared to individuals without OCD (OR=1.43, 95% CI=1.37-1.49; Table 1). In the analyses of individual AD, the risk was significantly elevated for Sjögren's syndrome (94% increase), celiac disease (76%), Guillain-Barré syndrome (71%), Crohn's disease (66%), Hashimoto's thyroiditis (59%), type 1 diabetes mellitus (56%), scarlet fever (52%), idiopathic thrombocytopenic purpura (51%), ulcerative colitis (41%), multiple sclerosis (41%), and psoriasis vulgaris (32%). Other AD (e.g., systemic lupus erythematosus or acute disseminated encephalomyelitis) were also associated with OCD, but power was limited, resulting in wide CI.