Chunk #35 — 3. Disruption of functional networks is associated with clinical impairment — 3.4 Neurobiological and clinical implications of network disruption
such as PET and cerebrospinal fluid sampling. In general, these techniques are non-invasive and safe. Task-free fMRI data can be obtained in eight minutes and added to the structural MRI most patients receive as part of a routine dementia evaluation, creating minimal new costs for data acquisition. Moreover, fMRI and EEG/MEG can be repeated as often as necessary (within clinical trials, for example), without radioactivity exposure concerns. On the other hand, some factors might hurdle the clinical implementation of these techniques in the short term. The expertise to analyse these data is yet confined to few centres and the analysis itself is time-consuming.
