paperKB
coga / coga-kb
Help
Sign in

Chunk #7 — Main Text — Genome-wide Association Studies

Source
The genetics of major depression.
Embedded
yes

Text

A simple summary of Table 1 is that nothing significant has been found and indeed many of the papers and reviews of this field make that point (e.g., Cohen-Woods et al., 2013). However, one paper claims a genome-wide significant association: a marker within a gene desert on chromosome 12 (Kohli et al., 2011). We need to consider not only whether this finding is likely to be true, but also whether the negative findings are meaningful. In short, how do we assess false-positive and false-negative rates in Table 1?