For our analysis, we treated the observations of an individual across multiple data replicates as repeated measures. To do this, we used the framework of a generalized linear mixed model (GLMM) as implemented in PROC GLIMMIX in SAS 9.2 [2] to estimate the MLEs and that take the repeated measures into account. As a result, the derived phenotype we used for analysis had a single value for each individual i given by:(3)
