Adjusting for cotinine and CPD separately attenuated these associations to varying degrees (maximum attenuation 29% for adjustment of rs578776 for cotinine) , as did adjustments for both cotinine and duration of smoking (maximum attenuation a substantial 43% for adjustment of rs578776 for as-measured cotinine and duration of smoking, Figure 2). Adjustment for regression-dilution bias corrected cotinine led to attenuation from OR=1.31 to OR=1.23 for rs16969968 and from OR=0.79 to OR=0.87 for rs578776 (Table 4).
