The NESARC has led to over 500 publications. The present study reviews 2011 NESARC research on the comorbidity of substance use and psychiatric disorders. Studies were identified by searching Pubmed for 2011 publications with the following: ‘National Epidemiologic Survey on Alcohol and Related Conditions’, NESARC, 43 093, or 34 653, along with alcohol, drug, substance or comorbidity. We organized this material as follows: metastructure of mental disorders; personality disorders; incidence and persistence; and treatment of major depression. In addition, less easily categorized studies were tabled for easy reference.