The datasets used for the analyses were obtained, after authorized access, from the National Center for Biotechnology Information (NCBI) database of Genotypes and Phenotypes (dbGaP; available at http://www.ncbi.nlm.nih.gov/gap) through dbGaP accession numbers: phs000200.v9.p3 for the WHI Clinical Trial and Observational Study16; and phs000397.v1.p1 for National Institute on Aging (NIA) Long Life Family Study (LLFS)19. All dbGaP dataset versions used in the current study are past their embargo periods. The Yale University Institutional Review Board approved the secondary analysis of these dbGaP datasets. WHI and LLFS studies were conducted in accordance with the relevant guidelines and regulations and their participants signed the informed consent to permit secondary analyses of their data.
