To address current gaps in the literature, the present study had the following aims: 1) to examine the change in prevalence of perceived great risk of regularly using cannabis (i.e., once or twice a week) over an 11-year period using the most recent currently available NSDUH survey data (i.e., during the years 2002–2012), stratified by sex; and 2) to explore characteristics associated with perceived great risk of cannabis use. To accomplish these aims, we used data from a nationally representative survey of non-institutionalized individuals ages 12 and older living in the U.S.