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Chunk #12 — Method — Source-based functional connectivity

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Electroencephalography Source Functional Connectivity Reveals Abnormal High-Frequency Communication Among Large-Scale Functional Networks in Depression.
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We computed EEG source-based functional connectivity using eLORETA software [17]. eLORETA is a linear inverse solution that can reconstruct cortical activity with correct localization from scalp EEG data [17]. The solution space consists of 6239 cortical gray matter voxels in a realistic head model [35] using the MNI152 template [36]. The LORETA algorithm (upon which eLORETA is based) has been validated in several studies combining LORETA with fMRI [37–39], PET [40, 41], simultaneous EEG-fMRI [42, 43] and intracranial recordings [44].