Chunk #23 — Results — Suppression of AEA/CB1 receptor signaling within the basolateral amygdala complex contributes to stress-induced activation of the HPA axis
There was a significant interaction between stress and administration of HU-210 into the MeA on serum corticosterone levels [F (1, 15) = 6.72, p < 0.03; Fig. 6] with subsequent analysis indicating that administration of HU-210 into the MeA prior to stress resulted in a significant facilitation of stress-induced corticosterone secretion (p < 0.02 relative to vehicle infused animals). There was no significant interaction between stress and infusion of HU-210 into the CeA [F (1, 13) = 0.3, p > 0.05; Fig. 6], nor a main effect of HU-210 administration into the CeA [F (1, 13) = 0.2, p > 0.05] on serum corticosterone levels, while there was a main effect of stress to increase serum corticosterone [F (1, 13) = 52.7, p < 0.001].
