The confirmation in a study of cross-generation correlations for SRE-5 and the expansion of these data to SRE-T are important for several reasons. First, these data add confidence to the conclusion that both scores from a simple retrospective measure of LR are familial and genetically influenced. Second, the demonstration of relatively robust correlations among brother-brother, sister-sister and father-son pairs, with a similar but nonsignificant pattern for mother-daughter pairs also indicates a genetic influence for SRE-T scores. Estimated heritability SRE-5 and SRE-T for same sex siblings were 53% and 39.5%, respectively. The conclusion that SRE-T scores are genetically influenced is also supported by a recent large-scale genome-wide association study (GWAS) that reported significant heritability for this measure and identified several gene variations with significance values of 10−8 or better (Lai et al, in submission).
