Other important information captured within drug–drug interactions entries include the evidence level, severity, description and management information. The evidence level is either encoded as 1 or 2, depending on if the information comes from a product monograph (encoded as 1) or other credible sources showing in vitro or clinical evidence for the interaction (encoded as 2). Within DrugBank, there are three severity levels for an interaction: ‘minor,’ ‘moderate,’ and ‘major.’ By our definition, minor interactions exist but are generally not clinically relevant, moderate interactions may or may not result in any substantial changes for a patient, and major interactions should prompt consideration of additional monitoring or treatment alteration by a HCP. The description and management fields are authored by curators to describe the interaction in more detail and steps that can assist in clinically managing the interaction, respectively.
