Genotyping was attempted for 1,110 MDD cases (655 recruited by GenRED I and 455 by GenRED II). The 1,636 control subjects were selected from the Molecular Genetics of Schizophrenia (MGS)19 sample. All subjects were of European ancestry. Clinical characteristics are summarized in Table 1 for samples that passed all quality control filters and were included in the analyses presented here.