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Chunk #32 — Methods — Accuracy and robustness evaluation — Chimeric validation

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Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure.
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We also tested whether the deconvolution results were dominated by the expression of any specific marker gene and ascertained the robustness of the inferred cellular population structure to any possibly altered expression of marker genes. To do so, we performed the deconvolution analysis discarding each of the marker genes one at a time and evaluated how these distributions differed in comparison to the full gene reference panel.