In order to illustrate the direction of the significant interaction for cocaine dependence we used the previously described CTQ high/low childhood adversity variable. Figure 4 Panel B shows that high childhood adversity was associated with increased cocaine dependence in both genotype groups, however, individuals with the rs11503014 11/12 genotype tended to have the greater risk compared with individuals with the 22 genotype (χ2 = 3.7, 1df, p = 0.054). The impact of high childhood adversity on cocaine addiction alone was only apparent in individuals with the 11/12 genotype (χ2 = 5.0, 1df, p = 0.026) (Figure 4, Panel A). The trend effect in the total group of patients was in the same direction as for the patients with cocaine dependence.
