The finding that the effects of GABRA2 haplotype were sex dependent was not expected. Since gender specific effects of other genetic variants have been routinely reported in other complex syndromes such as diabetes, obesity and hyperlipidemia [22, 23], it is not surprising to see that they may exist with respect to complex behavioral disorders as well. At the same time, if this finding is replicated, it may suggest that the pathways to ND in males and females are different and that careful dissection of these pathways may identify potential strategies to reduce the frequency of ND.
