The interactive graphical interface for displaying gene-gene relationships is based on open source Java code [59]. Genes form nodes in a graph and gene-gene relationships are edges. Clicking links and symbols leads to more detailed information. Symbol shape; font style; symbol, edge and font color as well as hover-over windows are used to provide as much information as possible. Gene symbol shape conveys whether or not that gene is involved in disease, gene symbol text color indicates whether there are deleterious SNPs. Subsets of genes containing one or more SNPs with population frequencies above some threshold may be highlighted (identifying those most likely to be involved in complex traits). A maximum of 300 genes are displayed in the graphical interface. These are genes most strongly associated with a query gene or a query disease. The threshold for displaying links between genes is adjustable to show only those most strongly linked, or all possible connections. Links may also be based on KEGG pathway connections or direct protein-protein interaction information, extracted from BIND [4]. Left clicking on a gene provides immediate access
