Precise control of fatty acid metabolism is essential. Defective fatty acid homeostasis regulation may induce lipotoxic tissue damage, including hepatic steatosis.1 Peroxisome proliferator-activated receptors (PPARs) are transcription factors that serve as fatty acid receptors and help regulate gene expression in response to fatty acid-derived stimuli.2 PPARs act as ligand-activated receptors, controlling target gene transcription. The three PPAR isotypes, PPARα, PPARβ/δ and PPARγ, display specific tissue expression patterns and control different biological functions,3 but all bind lipids and control lipid homeostasis in different tissues, including the liver.2
