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Chunk #6 — Material and Methods — Electronic health record-derived phenotypes

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Genome-wide association analysis of opioid use disorder: A novel approach using clinical data.
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To determine the positive predictive value of this claims-based approach, two authors performed chart reviews of 25 randomly-chosen cases and 25 controls, using Diagnostic and Statistical Manual of Mental Disorders (DSM–5) criteria. The positive predictive value among claims-identified cases was 80%, considerably higher than reported elsewhere(Carrell et al., 2020). The corresponding negative predictive value among controls was 100%.