with the largest heritability z-score. In several instances, data from the largest existing studies could not be shared or reflected a mixed-ancestry meta-analysis; in these cases, we deferred to the next largest European-ancestry study. We chose to retain datasets with an effective sample size greater than 5000 individuals and with estimated SNP heritability z-score ≥ 3, in keeping with previous recommendations (B. Bulik-Sullivan et al. 2015). This filter resulted in the exclusion of many relevant immune-related phenotypes, including eosinophilic esophagitis (Sleiman et al. 2014), granulomatosis with polyangiitis (Xie et al. 2013), IgA nephropathy (Kiryluk et al. 2014), HIV-related neurocognitive phenotypes (Levine et al. 2012), morning cortisol levels (Bolton et al. 2014), myeloid leukemias (Tapper et al. 2015), psoriatic arthritis (Ellinghaus et al. 2012), sarcoidosis (Fischer et al. 2012), and systemic sclerosis (Radstake et al. 2010). This also resulted in exclusion of several psychiatric and behavior phenotypes, including adolescent alcohol abuse (Edwards et al. 2015), anxiety-spectrum disorders (Otowa et al. 2016), borderline personality disorder (Lubke et al. 2014), language impairment (Jernigan et al. 2016), personality domains (five factor model; de Moor et al. 2012), post-traumatic stress disorder (L. E. Duncan et al. 2017), and reading disability (Eicher et al. 2013). We
