recent large GWAS of alcohol-related outcomes (Clarke et al., 2017; Jorgenson et al., 2017; Sanchez-Roige et al., 2017; Schumann et al., 2016) were also not supported. Indeed, no locus implicated by lead SNPs or gene-based analyses has been previously associated with alcohol use/misuse; these novel candidates require further investigation to determine the mechanisms by which they may influence alcohol sensitivity. However, the dearth of loci meeting strict correction thresholds prevents extensive interpretation of the current findings.
