All BMI-increasing alleles were associated with increased body weight, as expected from the correlation between BMI and body weight (Supplementary Table 2). To confirm an effect of the loci on adiposity rather than general body size, we tested association with body fat percentage, which was available in a subset of the stage 2 replication samples (n = 5,359–28,425) (Supplementary Table 2). The BMI-increasing allele showed directionally consistent effects on body fat percentage at 31 of the 32 confirmed loci (binomial sign test P = 1.54×10−8) (Supplementary Table 2).
