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Chunk #30 — Reasons to be Concerned about the Published cGxE Literature — The Ingredients of cGxE: The Choice of Genetic and Environmental Variables

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Candidate gene-environment interaction research: reflections and recommendations.
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In the enthusiasm surrounding the study of cGxE, many investigators have expanded their studies to include measures of G or E, when that was not the original focus of the study. This expansion into new areas has happened in both directions: researchers who have focused on carefully characterizing environmental effects have expanded their studies to include measured genes, and researchers who have focused on gene finding have expanded their studies to include measures of the environment. In theory this expansion of cross-disciplinary science is a positive development; however, an unfortunate corollary has been that the added component does not always represent the state of the science in the other respective field.