Analyses were adjusted for sex, age, % of predicted FEV1, and principal components for genetic ancestry. In total, meta-analysis included 1,113 current smokers for the current CPD phenotype. Lambda inflation factors were between 0.995 and 1.005 for individual cohorts (table 1), and 1.010 for meta-analytic p values (see online supplementary figure 5 for a Q-Q plot of meta-analysis). No SNPs showed meta-analytic association with p<10−6 (table 4). Among candidate SNPs, rs12461383 from the CYP2A6 locus was significantly associated with current CPD with the same effect direction as compared to previous GWAS on CPD (table 4). Candidate SNPs rs1801272 and rs7251570 showed borderline significant association with the same effect direction as compared to previous GWAS on CPD (table 4). We did not replicate, at a nominal p< 0.05, associations between SNPs in 7p14, 8p11 and 10q23 loci reported in previous GWAS on CPD in our analysis on current CPD (online supplementary table 3).
