et al., 2009; Meunier et al., 2009; Salvador et al., 2005), or pre-defined ROIs, often obtained from fMRI or fcMRI studies (Church et al., 2009; Dosenbach et al., 2007; Nelson et al., 2010). If the brain is a collection of functional units such as columns or functional areas, then nodes defined by undersampling, oversampling, or merging such units will necessarily result in a network that distorts, to some extent, the true composition of the brain’s network, and networks must be examined and interpreted accordingly.