networks than pairs that do not. We obtained a set of 17,540 experimentally validated interacting human protein pairs from EBI (European Bioinformatics Institute)/ IntAct26 and cross-referenced them with expressed genes in CTX, CN and CB. Mean topological overlap was significantly higher for interacting protein pairs than for randomly selected pairs in each brain region (CTX, P = 9.3 × 10−54; CN, P = 5.0 × 10−79; CB, P = 1.9 × 10−48; Supplementary Fig. 1 online). These results are consistent with findings in unicellular organisms27 and constitute the first global evidence that gene coexpression patterns are correlated with protein interactions in the human brain.
