To be eligible for the trial, participants must have smoked at least 10 cigarettes per day, have had a history of DSM-IV alcohol abuse or dependence and have had between 2 and 12 months of abstinence from alcohol prior to enrollment. The Alcohol Disorders section of the Structured Clinical Interview for Diagnosis for DSM-IV (First, Spitzer)16 was administered to establish a diagnosis of alcohol use disorder. Exclusion criteria were: (1) older than age 70; (2) diagnosis of schizophrenia; (3) current psychotic episode; (4) cardiac problems in the past 3 months; (5) uncontrolled hypertension; (6) history of seizure; (7) history of head injury (8) use of medications that lower the seizure threshold (additional details related to baseline characteristics and inclusion/exclusion criteria may be found in8). Of the 144 participants in the main trial, 90 provided a DNA sample for use in the genetic substudy.
