General information on study design and data availability are included in the Life Sciences Reporting Summary. Summary statistics based on the UK-Biobank and ICC samples and full results from the top 10,000 SNPs based on all three subsamples (i.e. including the 23andMe sample) will be available via LDhub (http://ldsc.broadinstitute.org/gwashare/). Codes and scripts are available upon reasonable request. Full summary statistics can only be provided after permission by 23andMe.