In the European-American discovery sample, the three top-ranked genes were SERINC2, KIAA0040, and IPO11, which contained eight top-ranked SNPs (p<5×10−7 as well as FDR<0.05), including 5 SNPs in SERINC2 (1.7×10−7≤p≤4.4×10−7), 2 SNPs in KIAA0040 (2.8×10−7≤p≤3.9×10−7; Zuo et al., 2012), and 1 SNP in IPO11 (p=2.8×10−7; Zuo et al., 2012). SERINC2 was the most significant risk gene for alcohol dependence and thus was the focus of the present study. KIAA0040 and IPO11 were reported previously (Zuo et al., 2012).
