The present study investigates differences in brain volume, DTI (i.e., FA, AD, and RD), and performance on neuropsychological tests among abstinent individuals with AUD (DSM-IV) relative to controls. The study also examines the association of these structural brain abnormalities with performance deficits on neuropsychological tests of planning and problem-solving ability, visuospatial memory span, and working memory. Based on previous research, we hypothesized that abstinent individuals with AUD would have smaller volumes in prefrontal cortical regions, hippocampal regions, basal ganglia regions, infratentorial and cerebellar regions, and lower microstructural integrity in WM regions, and that these abnormalities would be associated with poorer performance on neuropsychological tasks
