In the largest PTSD GWAS to date, we analyzed data from over one million individuals and identified a total of 95 independent risk loci across analyses, a five-fold increase over the most recent PTSD GWAS11–13. Compared to previous PTSD GWAS, we confirmed 14 out of 24 loci and identified 80 novel PTSD loci. Variant discovery in psychiatric GWAS follows a sigmoid curve, rapidly increasing once sample size passes a given threshold. This analysis passes that inflection point in PTSD65, thus representing a major milestone in PTSD genetics. Moreover, by leveraging complementary research methodologies, our findings provide new functional insights and a deeper characterization of the genetic architecture of PTSD.
