We expected that DSM-NicDep would be more genetically correlated with psychopathology than FTND, as has been found in clinical and epidemiological studies8. The point estimates of our genetic correlation analysis suggested that PTU (CPD + FTND) was the least associated with most indices of psychopathology, while both DSM-NicDep and ICD-TUD were more strongly associated with psychosocial indices. DSM-NicDep appeared to additionally index material deprivation more strongly than the other traits, while all four tobacco GWAS (DSM-NicDep, ICD-TUD, FTND and PTU) were equivalently related to respiratory (e.g., FEV1, Lung cancer) and metabolic markers of tobacco exposure.
