mood stabilizing medication for the BPD patients used to generate iPSC lines. Data for 87 individuals from four large Amish families, the largest being core Pedigree 110, location of the present research subjects, has been described [24]. The project Board and Panel were in agreement regarding medication compliance and the effectiveness of lithium. Several independent sources provided evidence about breakthrough episodes (due to poor compliance) and subsequent recovery with lithium as the mood stabilizing drug.