The host genes for these six SE include one lncRNA (LINC00665) and five protein-coding genes: NSUN4 (NOP2/Sun RNA Methyltransferase 4), SRRM2 (Serine/Arginine Repetitive Matrix 2), ELOVL7 (Elongation of Very Long Chain Fatty Acids Protein 7), DRC1 (Dynein Regulatory Complex Subunit 1) and TBC1D5 (TBC1 Domain Family Member 5). We searched the GTEx database and found that all six genes are expressed in the brain. We also found evidence in the literature that each of the six genes plays roles in alcohol-related diseases, neurological disorders, or immune response [49–55]. In addition, the elastic net models specified 51 genetic variants that are most explanatory to the PSI of the six SE (Supplementary Table S2). None of these explanatory variants have previously been associated with AUD in the NHGRI GWAS Catalog [56] or in a recent comprehensive genome-wide meta-analysis of problematic alcohol use [11].
