The most common form of developmental changes detected in the examined brains was focal dysplasia, which was observed in 11 (85%) of the autistic subjects. The morphology of focal dysplasias appears to reflect signs of abnormal migration, neuronal immaturity and altered cell arrangement, resulting in focal distortion of cytoarchitecture. In spite of similarities, the dysplastic changes in the neocortex and archicortex, dentate gyrus and cornu Ammonis and cerebellum also reveal a brain structure-specific pattern of dysplastic changes in autism.
