Chunk #33 — Reasons to be Concerned about the Published cGxE Literature — The Ingredients of cGxE: The Choice of Genetic and Environmental Variables — The Choice of “G”
for a diagnosis of Huntington’s disease (a dominant disorder). Imagine the confusion if a prenatal genetic counselor were to ascribe the same degree of vulnerability to a fetus that tests positive for one copy (a carrier, unaffected with disease) versus two copies (will manifest the disease) of the CFTR mutation! Although the action of genetic variants on complex traits is not monogenic, the technical specification of their purported mode of action is still significant.
